Anagrelide treatment in early pregnancy in a patient with JAK2V617F-positive essential thrombocythemia: case report and literature review

Sobas, Marta Anna; Pérez Encinas, Manuel Mateo; Rabuñal Martínez, María; Quinteiro García, Celsa; Bello López, José Luis
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URI: http://hdl.handle.net/20.500.11940/22721
PMID: 19887779
ESSN: 1421-9662
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Date issued
2009
Journal title
Acta Haematologica
Type of content
Artigo
DeCS
resultado del embarazo | complicaciones hematológicas del embarazo | embarazo | quinazolinas | trombocitemia esencial | recién nacido
MeSH
Pregnancy | Quinazolines | Infant, Newborn | Thrombocythemia, Essential | Female | Pregnancy Complications, Hematologic | Women | Pregnancy Outcome
CIE
Trombocitemia idiopática (D47.3)
Abstract
[EN] Essential thrombocythemia (ET) has 2 peaks of incidence: one is at 60 years of age, the other at 30 years. In women, the peak at the earlier age presents challenges for management in Nevertheless, HDU and ANA are not recommended during pregnancy because of embryo/ fetotoxic effects observed in animals . There are scarce clinical data on adverse incidents when ANA is used during pregnancy in humans. We present a successful outcome of a 32-year-old woman with ET who was treated with ANA before becoming pregnant and during early pregnancy.