Mostrar el registro sencillo del ítem
Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes
dc.contributor.author | Calviño-Sampedro, C. | |
dc.contributor.author | Gomez-Tourino, I. | |
dc.contributor.author | Cordero, O. J. | |
dc.contributor.author | Reche, P. A. | |
dc.contributor.author | Gómez-Perosanz, M. | |
dc.contributor.author | Sánchez-Trincado, J. L. | |
dc.contributor.author | Rodríguez, M. Á | |
dc.contributor.author | Martís Sueiro, Aurelio Manuel | |
dc.contributor.author | Viñuela Roldán, Juan | |
dc.contributor.author | Calviño, R. V. | |
dc.date.accessioned | 2021-11-30T09:33:25Z | |
dc.date.available | 2021-11-30T09:33:25Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0892-6638 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/30817223 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15757 | |
dc.description.abstract | Type 1 diabetes (T1D) results from the destruction of pancreatic beta-cells by the immune system, and CD8(+) T lymphocytes are critical actors in this autoimmune response. Pancreatic islets are surrounded by a mesh of nervous cells, the peri-insular Schwann cells, which are also targeted by autoreactive T lymphocytes and express specific antigens, such as the neurotrophic factor S100-beta. Previous work has shown increased proliferative responses to whole S100-beta in both human T1D patients and the nonobese diabetic (NOD) mouse model. We describe for the first time naturally processed and presented epitopes (NPPEs) presented by class I human leukocyte antigen-A*02:01 (A2.1) molecules derived from S100-beta. These NPPEs triggered IFN-gamma responses more frequently in both newly diagnosed and long-term T1D patients compared with healthy donors. Furthermore, the same NPPEs are recognized during the autoimmune response leading to diabetes in A2.1-transgenic NOD mice as early as 4 wk of age. Interestingly, when these NPPEs are used to prevent diabetes in this animal model, an acceleration of the disease is observed together with an exacerbation in insulitis and an increase in S100-beta-specific cytotoxicity in vaccinated animals. Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calvino-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gomez-Perosanz, M., Sanchez-Trincado, J. L., Rodriguez, M. A., Sueiro, A. M., Vinuela, J. E., Calvino, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-beta are targets of the autoimmune response in type 1 diabetes. | en |
dc.language.iso | eng | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Epitopes | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | HLA-A2 Antigen | * |
dc.subject.mesh | Mice | * |
dc.subject.mesh | Interferon-gamma | * |
dc.subject.mesh | Diabetes Mellitus | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | K562 Cells | * |
dc.subject.mesh | S100 Calcium Binding Protein beta Subunit | * |
dc.title | Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes | en |
dc.type | Artigo | es |
dc.authorsophos | Calviño-Sampedro, C. | |
dc.authorsophos | Gomez-Tourino, I. | |
dc.authorsophos | Cordero, O. J. | |
dc.authorsophos | Reche, P. A. | |
dc.authorsophos | Gómez-Perosanz, M. | |
dc.authorsophos | Sánchez-Trincado, J. L. | |
dc.authorsophos | Rodríguez, M. Á | |
dc.authorsophos | Sueiro, A. M. | |
dc.authorsophos | Viñuela, J. E. | |
dc.authorsophos | Calviño, R. V. | |
dc.identifier.doi | 10.1096/fj.201802270R | |
dc.identifier.pmid | 30817223 | |
dc.identifier.sophos | 31700 | |
dc.issue.number | 5 | es |
dc.journal.title | FASEB JOURNAL | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Análise clínicos | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Endocrinoloxía | es |
dc.page.initial | 6390 | es |
dc.page.final | 6401 | es |
dc.relation.publisherversion | https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201802270R?download=true | es |
dc.rights.accessRights | openAccess | es |
dc.subject.decs | animales | * |
dc.subject.decs | antígeno HLA-A2 | * |
dc.subject.decs | subunidad beta de la proteína de unión al calcio S100 | * |
dc.subject.decs | células K562 | * |
dc.subject.decs | humanos | * |
dc.subject.decs | epítopos | * |
dc.subject.decs | diabetes mellitus | * |
dc.subject.decs | ratones | * |
dc.subject.decs | interferón gamma | * |
dc.subject.keyword | CHUS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 33 | es |