Mostrar el registro sencillo del ítem

dc.contributor.authorSanjurjo Rodríguez, Clara
dc.contributor.authorCastro Viñuelas, Rocio
dc.contributor.authorPiñeiro Ramil, María
dc.contributor.authorRodríguez Fernández, Silvia
dc.contributor.authorFuentes Boquete, Isaac
dc.contributor.authorBLANCO GARCIA, FRANCISCO JAVIER 
dc.contributor.authorDíaz Prado, Silvia María
dc.date.accessioned2022-03-04T07:46:48Z
dc.date.available2022-03-04T07:46:48Z
dc.date.issued2020
dc.identifier.issn1661-6596
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32854405es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16168
dc.description.abstractInduced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of differentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders affecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal diseases are one of the major causes of disability worldwide and impose an important socio-economic burden. To date there is neither cure nor proven approach for effectively treating most of these conditions and therefore new strategies involving the use of cells have been increasingly investigated in the recent years. Nevertheless, some limitations related to the safety and differentiation protocols among others remain, which humpers the translational application of these strategies. Nonetheless, the potential is indisputable and iPSCs are likely to be a source of different types of cells useful in the musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration preclinical studies that have been carried out in the musculoskeletal field by using iPSCs.es
dc.language.isoenes
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshCell Differentiation*
dc.subject.meshMusculoskeletal Diseases*
dc.subject.meshHumans*
dc.subject.meshRegenerative Medicine*
dc.subject.meshBiomedical Research*
dc.subject.meshInduced Pluripotent Stem Cells*
dc.subject.meshStem Cell Transplantation*
dc.subject.meshOrgan Specificity*
dc.titleVersatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseasesen
dc.typeJournal Articlees
dc.authorsophosSanjurjo-Rodríguez, Clara;Castro-Viñuelas, Rocío;Piñeiro-Ramil, María;Rodríguez-Fernández, Silvia;Fuentes-Boquete, Isaac;Blanco, Francisco J;Díaz-Prado, Silvia
dc.identifier.doi10.3390/ijms21176124
dc.identifier.pmid32854405
dc.identifier.sophos35643
dc.issue.number17es
dc.journal.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/ijms/ijms-21-06124/article://deploy/ijms-21-06124-v2.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decsenfermedades musculoesqueléticas *
dc.subject.decsinvestigación biomédica *
dc.subject.decstrasplante de células madre *
dc.subject.decsmedicina regenerativa *
dc.subject.decshumanos *
dc.subject.decsdiferenciación celular *
dc.subject.decscélulas madre pluripotentes inducidas *
dc.subject.decsespecificidad de órganos *
dc.subject.keywordINIBICes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number21es


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional