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Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases
dc.contributor.author | Sanjurjo Rodríguez, Clara | |
dc.contributor.author | Castro Viñuelas, Rocio | |
dc.contributor.author | Piñeiro Ramil, María | |
dc.contributor.author | Rodríguez Fernández, Silvia | |
dc.contributor.author | Fuentes Boquete, Isaac | |
dc.contributor.author | BLANCO GARCIA, FRANCISCO JAVIER | |
dc.contributor.author | Díaz Prado, Silvia María | |
dc.date.accessioned | 2022-03-04T07:46:48Z | |
dc.date.available | 2022-03-04T07:46:48Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32854405 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16168 | |
dc.description.abstract | Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of differentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders affecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal diseases are one of the major causes of disability worldwide and impose an important socio-economic burden. To date there is neither cure nor proven approach for effectively treating most of these conditions and therefore new strategies involving the use of cells have been increasingly investigated in the recent years. Nevertheless, some limitations related to the safety and differentiation protocols among others remain, which humpers the translational application of these strategies. Nonetheless, the potential is indisputable and iPSCs are likely to be a source of different types of cells useful in the musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration preclinical studies that have been carried out in the musculoskeletal field by using iPSCs. | es |
dc.language.iso | en | es |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Cell Differentiation | * |
dc.subject.mesh | Musculoskeletal Diseases | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Regenerative Medicine | * |
dc.subject.mesh | Biomedical Research | * |
dc.subject.mesh | Induced Pluripotent Stem Cells | * |
dc.subject.mesh | Stem Cell Transplantation | * |
dc.subject.mesh | Organ Specificity | * |
dc.title | Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases | en |
dc.type | Journal Article | es |
dc.authorsophos | Sanjurjo-Rodríguez, Clara;Castro-Viñuelas, Rocío;Piñeiro-Ramil, María;Rodríguez-Fernández, Silvia;Fuentes-Boquete, Isaac;Blanco, Francisco J;Díaz-Prado, Silvia | |
dc.identifier.doi | 10.3390/ijms21176124 | |
dc.identifier.pmid | 32854405 | |
dc.identifier.sophos | 35643 | |
dc.issue.number | 17 | es |
dc.journal.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC) | |
dc.relation.publisherversion | https://mdpi-res.com/d://attachment/ijms/ijms-21-06124/article://deploy/ijms-21-06124-v2.pdf | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | enfermedades musculoesqueléticas | * |
dc.subject.decs | investigación biomédica | * |
dc.subject.decs | trasplante de células madre | * |
dc.subject.decs | medicina regenerativa | * |
dc.subject.decs | humanos | * |
dc.subject.decs | diferenciación celular | * |
dc.subject.decs | células madre pluripotentes inducidas | * |
dc.subject.decs | especificidad de órganos | * |
dc.subject.keyword | INIBIC | es |
dc.typefides | Artículo de Revisión | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 21 | es |