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Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder
dc.contributor.author | Couce Pico, María Luz | |
dc.contributor.author | Sánchez Pintos, Paula | |
dc.contributor.author | González Vioque, Emiliano | |
dc.contributor.author | Leis Trabazo, María Rosaura | |
dc.date.accessioned | 2022-04-29T10:26:49Z | |
dc.date.available | 2022-04-29T10:26:49Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33019743 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16611 | |
dc.description.abstract | Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramer's V, 0.28) and intolerance (Cramer's V, 0.54). The frequency of the LNP genotype (p = 0.002) and of malabsorption and intolerance increased with age (p = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Breath Tests | * |
dc.subject.mesh | Cross-Sectional Studies | * |
dc.subject.mesh | Lactase | * |
dc.subject.mesh | Adolescent | * |
dc.subject.mesh | Dairy Products | * |
dc.subject.mesh | Phenotype | * |
dc.subject.mesh | Gastrointestinal Diseases | * |
dc.subject.mesh | Diet | * |
dc.subject.mesh | Lactose Intolerance | * |
dc.subject.mesh | Hydrogen | * |
dc.subject.mesh | Gene Frequency | * |
dc.title | Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder | en |
dc.type | Journal Article | es |
dc.authorsophos | Couce, M. L.;Sanchez-Pintos, P.;Gonzalez-Vioque, E.;Leis, R. | |
dc.identifier.doi | 10.3390/nu12103017 | |
dc.identifier.pmid | PMC7601291 | |
dc.identifier.sophos | 39617 | |
dc.issue.number | 10 | es |
dc.journal.title | Nutrients | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatría | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neonatoloxía | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | fenotipo | * |
dc.subject.decs | hidrógeno | * |
dc.subject.decs | enfermedades gastrointestinales | * |
dc.subject.decs | frecuencia génica | * |
dc.subject.decs | pruebas espiratorias | * |
dc.subject.decs | humanos | * |
dc.subject.decs | productos lácteos | * |
dc.subject.decs | estudios transversales | * |
dc.subject.decs | lactasa | * |
dc.subject.decs | dieta | * |
dc.subject.decs | intolerancia a la lactosa | * |
dc.subject.decs | adolescente | * |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 12 | es |