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dc.contributor.authorCouce Pico, María Luz 
dc.contributor.authorSánchez Pintos, Paula 
dc.contributor.authorGonzález Vioque, Emiliano
dc.contributor.authorLeis Trabazo, María Rosaura 
dc.date.accessioned2022-04-29T10:26:49Z
dc.date.available2022-04-29T10:26:49Z
dc.date.issued2020
dc.identifier.issn2072-6643
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33019743es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16611
dc.description.abstractGenetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramer's V, 0.28) and intolerance (Cramer's V, 0.54). The frequency of the LNP genotype (p = 0.002) and of malabsorption and intolerance increased with age (p = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHumans*
dc.subject.meshBreath Tests*
dc.subject.meshCross-Sectional Studies*
dc.subject.meshLactase*
dc.subject.meshAdolescent*
dc.subject.meshDairy Products*
dc.subject.meshPhenotype*
dc.subject.meshGastrointestinal Diseases*
dc.subject.meshDiet*
dc.subject.meshLactose Intolerance*
dc.subject.meshHydrogen*
dc.subject.meshGene Frequency*
dc.titleClinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorderen
dc.typeJournal Articlees
dc.authorsophosCouce, M. L.;Sanchez-Pintos, P.;Gonzalez-Vioque, E.;Leis, R.
dc.identifier.doi10.3390/nu12103017
dc.identifier.pmidPMC7601291
dc.identifier.sophos39617
dc.issue.number10es
dc.journal.titleNutrientses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neonatoloxíaes
dc.rights.accessRightsopenAccess
dc.subject.decsfenotipo*
dc.subject.decshidrógeno*
dc.subject.decsenfermedades gastrointestinales*
dc.subject.decsfrecuencia génica*
dc.subject.decspruebas espiratorias*
dc.subject.decshumanos*
dc.subject.decsproductos lácteos*
dc.subject.decsestudios transversales*
dc.subject.decslactasa*
dc.subject.decsdieta*
dc.subject.decsintolerancia a la lactosa*
dc.subject.decsadolescente*
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number12es


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Atribución 4.0 Internacional
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