TY  - JOUR 
AU  - De Andrés González, Mª Carmen
AU  - Imagawa, K.
AU  - Hashimoto, K.
AU  - González Martínez-Pedrayo, Antonio
AU  - Roach, H. I.
AU  - Goldring, M. B.
AU  - Oreffo, R. O. C.
PY  - 2013
SN  - 0004-3591
UR  - http://hdl.handle.net/20.500.11940/3484
AB  - OBJECTIVE: To investigate whether the abnormal expression of inducible nitric oxide synthase (iNOS) by osteoarthritic (OA) human chondrocytes is associated with changes in the DNA methylation status in the promoter and/or enhancer elements of iNOS....
LA  - eng
KW  - Aged
KW  - Aged, 80 and over
KW  - Cartilage, Articular
KW  - Chondrocytes
KW  - CpG Islands
KW  - DNA Methylation
KW  - Enhancer Elements, Genetic
KW  - Female
KW  - Gene Expression Regulation, Enzymologic
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - NF-kappa B
KW  - Nitric Oxide Synthase Type II
KW  - Osteoarthritis, Hip
KW  - Primary Cell Culture
KW  - Promoter Regions, Genetic/physiology
TI  - Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes
DO  - 10.1002/art.37806
T2  - ARTHRITIS AND RHEUMATISM
M2  - 732
VL  - 65
ER  -