TY  - JOUR 
AU  - Contreras, Cristina
AU  - González-García, Ismael
AU  - Martínez-Sánchez, Noelia
AU  - Seoane-Collazo, Patricia
AU  - Jacas, Jordi
AU  - Morgan, Donald A
AU  - Serra, Dolors
AU  - Gallego, Rosalía
AU  - González García, Francisco
AU  - Casals, Núria
AU  - Nogueiras, Rubén
AU  - Rahmouni, Kamal
AU  - Diéguez, Carlos
AU  - López, Miguel
PY  - 2014
SN  - 2211-1247
UR  - http://hdl.handle.net/20.500.11940/4538
AB  - Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT)...
LA  - eng
KW  - Adipose Tissue, Brown
KW  - Ceramides
KW  - Hypothalamus
KW  - Insulin Resistance
KW  - Obesity
KW  - Thermogenesis
TI  - Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
DO  - 10.1016/j.celrep.2014.08.057
T2  - Cell Reports
M2  - 366
VL  - 9
ER  -