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dc.contributor.authorFerreirós López, Alba
dc.contributor.authorPedrosa Lado, Pablo
dc.contributor.authorDa Silva Alvarez, Sabela
dc.contributor.authorTriana Martínez, Francisco
dc.contributor.authorVilas Martínez, Jessica María
dc.contributor.authorPicallos-Rabina, P.
dc.contributor.authorGonzález, P.
dc.contributor.authorGómez, M.
dc.contributor.authorLi, H.
dc.contributor.authorGarcía-Caballero, T.
dc.contributor.authorGonzález Barcia, Miguel 
dc.contributor.authorVidal, A.
dc.contributor.authorCollado Rodríguez, Manuel
dc.date.accessioned2021-10-04T09:40:29Z
dc.date.available2021-10-04T09:40:29Z
dc.date.issued2019
dc.identifier.issn2213-6711
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31056476es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15439
dc.description.abstractInduction of pluripotency in somatic cells with defined genetic factors has been successfully used to investigate the mechanisms of disease initiation and progression. Cellular reprogramming and oncogenic transformation share common features; both involve undergoing a dramatic change in cell identity, and immortalization is a key step for cancer progression that enhances reprogramming. However, there are very few examples of complete successful reprogramming of tumor cells. Here we address the effect of expressing an active oncogene, RAS, on the process of reprogramming and found that, while combined expression with reprogramming factors enhanced dedifferentiation, expression within the context of neoplastic transformation impaired reprogramming. RAS induces expression changes that promote loss of cell identity and acquisition of stemness in a paracrine manner and these changes result in reprogramming when combined with reprogramming factors. When cells carry cooperating oncogenic defects, RAS drives cells into an incompatible cellular fate of malignancy.en
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.meshHumans*
dc.subject.meshCells*
dc.subject.meshMice*
dc.subject.meshAnimals*
dc.subject.meshGene Expression Regulation*
dc.titleContext-Dependent Impact of RAS Oncogene Expression on Cellular Reprogramming to Pluripotencyes
dc.typeArtigoes
dc.authorsophosFerreirós, A.
dc.authorsophosPedrosa, P.
dc.authorsophosDa Silva-Álvarez, S.
dc.authorsophosTriana-Martínez, F.
dc.authorsophosVilas, J. M.
dc.authorsophosPicallos-Rabina, P.
dc.authorsophosGonzález, P.
dc.authorsophosGómez, M.
dc.authorsophosLi, H.
dc.authorsophosGarcía-Caballero, T.
dc.authorsophosGonzález-Barcia, M.
dc.authorsophosVidal, A.
dc.authorsophosCollado, M.
dc.identifier.doi10.1016/j.stemcr.2019.04.006
dc.identifier.pmid31056476
dc.identifier.sophos30737
dc.issue.number5es
dc.journal.titleStem Cell Reportses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Farmacia
dc.page.initial1099es
dc.page.final1112es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524732/pdf/main.pdf
dc.rights.accessRightsopenAccess
dc.subject.decsanimales*
dc.subject.decshumanos*
dc.subject.decscélulas*
dc.subject.decsregulación de la expresión génica*
dc.subject.decsratones*
dc.subject.keywordIDIS
dc.subject.keywordCHUS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number12es


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Attribution-NonCommercial-NoDerivatives 4.0 International
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