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dc.contributor.authorGonzalez-Alvaro, I.
dc.contributor.authorCastrejon, I.
dc.contributor.authorCarmona, L.
dc.contributor.authorDougados, M.
dc.contributor.authorHuizinga, T.
dc.contributor.authorAbu Shakra, M.
dc.contributor.authorAlberts, A.
dc.contributor.authorLopez, M. A.
dc.contributor.authorAmital, H.
dc.contributor.authorAringer, M.
dc.contributor.authorAslanidis, S.
dc.contributor.authorBerenbaum, F.
dc.contributor.authorBijlsma, H.
dc.contributor.authorGarcia, F. J. B.
dc.contributor.authorBliddal, H.
dc.contributor.authorBorofsky, M.
dc.contributor.authorBrocq, O.
dc.contributor.authorBuldakov, S.
dc.contributor.authorCantini, F.
dc.contributor.authorPerez, L. C.
dc.contributor.authorChahade, W.
dc.contributor.authorCiconelli, R.
dc.contributor.authorCodreanu, C.
dc.contributor.authorDahlqvist, S. R.
dc.contributor.authorDamjanov, N.
dc.contributor.authorDiamantopoulos, A.
dc.contributor.authorDimdina, L.
dc.contributor.authorDimic, A.
dc.contributor.authorDorokhov, A.
dc.contributor.authorDubikov, A.
dc.contributor.authorFadienko, G.
dc.contributor.authorFano, N.
dc.contributor.authorFerreira, G.
dc.contributor.authorGabrielli, A.
dc.contributor.authorGaffney, K.
dc.contributor.authorGaudin, P.
dc.contributor.authorGerlag, D. M.
dc.contributor.authorGerli, R.
dc.contributor.authorGoncalves, C. R.
dc.contributor.authorHansen, M. S.
dc.contributor.authorHanvivadhanakul, P.
dc.contributor.authorHoili, C.
dc.contributor.authorHou, A.
dc.contributor.authorHunter, J.
dc.contributor.authorIlic, T.
dc.contributor.authorIonescu, R.
dc.contributor.authorKaine, J.
dc.contributor.authorKakurina, N.
dc.contributor.authorKamalova, R.
dc.contributor.authorKelly, T.
dc.contributor.authorKnyazeva, L.
dc.contributor.authorKrumina, L.
dc.contributor.authorKurthen, R.
dc.contributor.authorLagrone, R. P.
dc.contributor.authorLapadula, G.
dc.contributor.authorLavrentjevs, V.
dc.contributor.authorLawson, J. G.
dc.contributor.authorLazic, Z.
dc.contributor.authorLejnieks, A.
dc.contributor.authorLevy, Y.
dc.contributor.authorLexberg, A.
dc.contributor.authorMader, R.
dc.contributor.authorMariette, X.
dc.contributor.authorMarkovits, D.
dc.contributor.authorMola, E. M.
dc.contributor.authorMaugars, Y.
dc.contributor.authorGuarch, J. M.
dc.contributor.authorMazurov, V. I.
dc.contributor.authorMikkelsen, K.
dc.contributor.authorVergles, J. M.
dc.contributor.authorNabizadeh, S.
dc.contributor.authorNanagara, R.
dc.contributor.authorNasonov, E. L.
dc.contributor.authorSarabia, F. N.
dc.contributor.authorNeumann, T.
dc.contributor.authorNovak, S.
dc.contributor.authorOlech, E.
dc.contributor.authorOza, M.
dc.contributor.authorParan, D.
dc.contributor.authorParsik, E.
dc.contributor.authorPegram, S.
dc.contributor.authorSuarez, M. P.
dc.contributor.authorPopova, T.
dc.contributor.authorPuechal, X.
dc.contributor.authorRaja, N.
dc.contributor.authorRidley, D.
dc.contributor.authorRosner, I.
dc.contributor.authorRubbert-Roth, A.
dc.contributor.authorRudin, A.
dc.contributor.authorSaraux, A.
dc.contributor.authorSaulite-Kandevica, D.
dc.contributor.authorSettas, L.
dc.contributor.authorSfikakis, P.
dc.contributor.authorSheeran, T.
dc.contributor.authorSizikov, A.
dc.contributor.authorStamenkovic, D.
dc.contributor.authorStefanovic, D.
dc.contributor.authorStolow, J. B.
dc.contributor.authorTan, A. L.
dc.contributor.authorTebib, J.
dc.contributor.authorTishler, M.
dc.contributor.authorTony, H. P.
dc.contributor.authorTroum, O. M.
dc.contributor.authorUaratanawong, S.
dc.contributor.authorAngulo, E. U.
dc.contributor.authorValenzuela, G.
dc.contributor.authorvan der Laken, K.
dc.contributor.authorVan Laar, J.
dc.contributor.authorvan Riel, Plcm
dc.contributor.authorVasilopoulos, D.
dc.contributor.authorVeldi, T.
dc.contributor.authorVinogradova, I.
dc.contributor.authorVosse, D.
dc.contributor.authorWassenberg, S.
dc.contributor.authorWeidmann, C.
dc.contributor.authorWeitz, M.
dc.contributor.authorWollenhaupt, J.
dc.contributor.authorXavier, R.
dc.contributor.authorYakupova, S.
dc.contributor.authorZagar, I.
dc.contributor.authorZavgorodnaja, T.
dc.contributor.authorZemerova, E.
dc.contributor.authorZisman, D.
dc.contributor.authorZonova, E.
dc.contributor.authorCamona, L.
dc.contributor.authorAlcazar, L. A.
dc.contributor.authorde Miguel, C. A.
dc.contributor.authorSanchez, J. L. A.
dc.contributor.authorDiez, A. A.
dc.contributor.authorCriado, A. B.
dc.contributor.authorGualda, E. B.
dc.contributor.authorSerrano, M. A. B.
dc.contributor.authorAudera, J. B.
dc.contributor.authorFabregat, J. B.
dc.contributor.authorHernan, G. B.
dc.contributor.authorFernandez, N. C.
dc.contributor.authorCasado, E.
dc.contributor.authorMendez, L. C.
dc.contributor.authorCoro, M. C.
dc.contributor.authorDiaz, J. L. C.
dc.contributor.authorCuesta, E.
dc.contributor.authorAreste, J. F.
dc.contributor.authorGonzalez, M. F.
dc.contributor.authorIzquierdo, M. G.
dc.contributor.authorGarcía Meijide, Juan
dc.contributor.authorGomez, M. C. G.
dc.contributor.authorUbeda, E. G.
dc.contributor.authorCenteno, E. G.
dc.contributor.authorVaquero, C. G.
dc.contributor.authorFernandez, M. J. G.
dc.contributor.authorGomez, M. L. G.
dc.contributor.authorHernandez, T. G.
dc.contributor.authorGomez, C. G. M.
dc.contributor.authorDelgado, Y. G.
dc.contributor.authorMasmitja, J. G.
dc.contributor.authordel Rio, A. H.
dc.contributor.authorInstxaurbe, A. R.
dc.contributor.authorOyarzabal, M. V. I.
dc.contributor.authorPalop, J.
dc.contributor.authorMas, A. J.
dc.contributor.authorNavarro, E. J.
dc.contributor.authorPadro, M. L.
dc.contributor.authorLongo, F. J. L.
dc.contributor.authorSantamaria, E. L.
dc.contributor.authorManzano, J. M.
dc.contributor.authorRuiz, F. J. M.
dc.contributor.authorBernardo, I. M.
dc.contributor.authorGonzalez, L. M.
dc.contributor.authorMazzucheli, R.
dc.contributor.authorSan Idelfonso, M. M.
dc.contributor.authorHernandez, A. N.
dc.contributor.authorEspanol, A. P.
dc.contributor.authorCallizo, E. P.
dc.contributor.authorDonate, J. Q.
dc.contributor.authorLopez, P. R.
dc.contributor.authorRedondo, J. R.
dc.contributor.authorGomez, M. R.
dc.contributor.authorLopez, M. R.
dc.contributor.authorPardo, R. R.
dc.contributor.authorAlvarez, J. S.
dc.contributor.authorSala, R. S.
dc.contributor.authorRey, J. S. R.
dc.contributor.authorMarsa, X. T.
dc.contributor.authorMartin, M. T.
dc.contributor.authorMartin, M. C. T.
dc.contributor.authorGarnica, I. U.
dc.contributor.authorde Diego, J. P. V.
dc.contributor.authorValls, M.
dc.contributor.authorGarcia, V. V.
dc.contributor.authorMontejo, P. Z.
dc.contributor.authorTabernero, J. Z.
dc.contributor.authorBalsa, A.
dc.contributor.authorSanmarti, R.
dc.contributor.authorCabezas, J. A.
dc.contributor.authorCantalejo, M.
dc.contributor.authorChamizo, E.
dc.contributor.authorCiruelo, E.
dc.contributor.authorCorrales, A.
dc.contributor.authorCruz, A.
dc.contributor.authorDiaz, C.
dc.contributor.authorFiter, J.
dc.contributor.authorFreire, M. M.
dc.contributor.authorGalindo, M.
dc.contributor.authorde Vicuna, M. R. G.
dc.contributor.authorGelman, S. M.
dc.contributor.authorCrespo, R. G.
dc.contributor.authorFernandez, C. G.
dc.contributor.authorGracia, A.
dc.contributor.authorGranados, J.
dc.contributor.authorGuzman, M. A.
dc.contributor.authorIrigoyen, M. V.
dc.contributor.authorJuan, A.
dc.contributor.authorJuanola, X.
dc.contributor.authorLaiz, A.
dc.contributor.authorManero, F. J.
dc.contributor.authorMartinez, A.
dc.contributor.authorMartinez, F.
dc.contributor.authorMata, C.
dc.contributor.authorMaymo, J.
dc.contributor.authorNavarro, F. J.
dc.contributor.authorPeiro, E.
dc.contributor.authorPerez, F.
dc.contributor.authorPerez, G.
dc.contributor.authorPerez, M.
dc.contributor.authorPujol, M.
dc.contributor.authorQuiros, J.
dc.contributor.authorRibas, B.
dc.contributor.authorRiera, M.
dc.contributor.authorRivera, J.
dc.contributor.authorRodríguez Gómez, Manuel 
dc.contributor.authorRosello, R.
dc.contributor.authorTenorio, M.
dc.contributor.authorToyos, F. J.
dc.date.accessioned2021-11-04T10:50:20Z
dc.date.available2021-11-04T10:50:20Z
dc.date.issued2019
dc.identifier.issn1932-6203
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30969989es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457549/pdf/pone.0214717.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30969989es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457549/pdf/pone.0214717.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15647
dc.description.abstractOBJECTIVE: To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. METHODS: Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (DeltaGDA-Phy). RESULTS: DeltaHUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using DeltaGDA-Phy as gold standard. CONCLUSION: HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshClinical Trials as Topic*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshAntirheumatic Agents*
dc.subject.meshLinear Models*
dc.subject.meshSeverity of Illness Index*
dc.subject.meshArthritis*
dc.subject.meshCohort Studies*
dc.titleThe comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activityes
dc.typeArtigoes
dc.contributor.authorcorpAct-Ray Study Group
dc.contributor.authorcorpProar Study Group
dc.contributor.authorcorpEmecar Study Group
dc.identifier.doi10.1371/journal.pone.0214717
dc.identifier.pmid30969989
dc.identifier.sophos31249
dc.issue.number4es
dc.journal.titlePLoS Onees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourensees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccesses
dc.subject.decsmodelos lineales*
dc.subject.decsresultado del tratamiento*
dc.subject.decsensayos clínicos como asunto*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsestudios de cohortes*
dc.subject.decsantirreumáticos*
dc.subject.decsíndice de gravedad de la enfermedad*
dc.subject.decsartritis*
dc.subject.keywordCHUOes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number14es


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Atribución 4.0 Internacional
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