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dc.contributor.authorT., Aasen
dc.contributor.authorE., Leithe
dc.contributor.authorS.V., Graham
dc.contributor.authorP., Kameritsch
dc.contributor.authorMayan Santos, María Dolores
dc.contributor.authorM., Mesnil
dc.contributor.authorK., Pogoda
dc.contributor.authorA., Tabernero
dc.date.accessioned2022-02-01T12:59:24Z
dc.date.available2022-02-01T12:59:24Z
dc.date.issued2019
dc.identifier.issn0950-9232
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555763/pdf/41388_2019_Article_741.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16051
dc.description.abstractGap junctions comprise arrays of intercellular channels formed by connexin proteins and provide for the direct communication between adjacent cells. This type of intercellular communication permits the coordination of cellular activities and plays key roles in the control of cell growth and differentiation and in the maintenance of tissue homoeostasis. After more than 50 years, deciphering the links among connexins, gap junctions and cancer, researchers are now beginning to translate this knowledge to the clinic. The emergence of new strategies for connexin targeting, combined with an improved understanding of the molecular bases underlying the dysregulation of connexins during cancer development, offers novel opportunities for clinical applications. However, different connexin isoforms have diverse channel-dependent and -independent functions that are tissue and stage specific. This can elicit both pro- and anti-tumorigenic effects that engender significant challenges in the path towards personalised medicine. Here, we review the current understanding of the role of connexins and gap junctions in cancer, with particular focus on the recent progress made in determining their prognostic and therapeutic potential.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshConnexins*
dc.subject.meshCytosol*
dc.subject.meshNeoplasm Invasiveness*
dc.subject.meshNeoplasm Metastasis*
dc.subject.meshCell Proliferation*
dc.subject.meshAnimals*
dc.subject.meshGap Junctions*
dc.subject.meshProtein Isoforms*
dc.subject.meshCell Differentiation*
dc.subject.meshCell Membrane*
dc.subject.meshCell Communication*
dc.subject.meshHomeostasis*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshCarcinogenesis*
dc.subject.meshNeoplastic Stem Cells*
dc.subject.meshTranslational Medical Research*
dc.subject.meshTumor Microenvironment*
dc.subject.meshGene Expression Regulation*
dc.subject.meshNeoplasms*
dc.subject.meshPrognosis*
dc.titleConnexins in cancer: bridging the gap to the clinicen
dc.typeArtigoes
dc.identifier.doi10.1038/s41388-019-0741-6
dc.identifier.pmid30814684
dc.identifier.sophos33999
dc.issue.number23es
dc.journal.titleONCOGENEes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.page.initial4429es
dc.page.final4451es
dc.rights.accessRightsopenAccesses
dc.subject.decsisoformas de proteínas*
dc.subject.decspronóstico*
dc.subject.decsresultado del tratamiento*
dc.subject.decsanimales*
dc.subject.decscitosol*
dc.subject.decscélulas madre neoplásicas*
dc.subject.decsmetástasis neoplásica*
dc.subject.decsdiferenciación celular*
dc.subject.decsneoplasias*
dc.subject.decsmembrana celular*
dc.subject.decsuniones comunicantes*
dc.subject.decsregulación de la expresión génica*
dc.subject.decscarcinogénesis*
dc.subject.decsinvasividad neoplásica*
dc.subject.decsinvestigación médica traslacional*
dc.subject.decsconexinas*
dc.subject.decscomunicación celular*
dc.subject.decshomeostasis*
dc.subject.decsproliferación celular*
dc.subject.decsmicroambiente tumoral*
dc.subject.decshumanos*
dc.subject.keywordINIBICes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number38es


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