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Metabolic actions of the growth hormone-insulin growth factor-1 axis and its interaction with the central nervous system

dc.contributor.authorAL-MASSADI IGLESIAS, OMAR 
dc.contributor.authorParini, Paolo
dc.contributor.authorFerno, Johan
dc.contributor.authorLuquet, Serge
dc.contributor.authorQuiñones, Mar
dc.date.accessioned2022-09-02T11:56:49Z
dc.date.available2022-09-02T11:56:49Z
dc.date.issued2022
dc.identifier.issn1389-9155
dc.identifier.otherhttps://doi.org/10.1007/s11154-022-09732-xes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16962
dc.description.abstractThe growth hormone/insulin growth factor-1 axis is a key endocrine system that exerts profound efects on metabolism by its actions on diferent peripheral tissues but also in the brain. Growth hormone together with insulin growth factor-1 perform metabolic adjustments, including regulation of food intake, energy expenditure, and glycemia. The dysregulation of this hepatic axis leads to diferent metabolic disorders including obesity, type 2 diabetes or liver disease. In this review, we discuss how the growth hormone/insulin growth factor-1 axis regulates metabolism and its interactions with the central nervous system. Finally, we state our vision for possible therapeutic uses of compounds based in the components of this hepatic axis.es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)es
dc.description.sponsorshipMinisterio de Ciencia e innovaciónes
dc.description.sponsorshipUnión Europeaes
dc.description.sponsorshipFundación de la Sociedad Gallega de Endocrinología y nutriciónes
dc.description.sponsorshipCentro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn)es
dc.description.sponsorshipEuropean Union/HUMANes
dc.format.extent12 p.es
dc.language.isoenges
dc.subject.meshLiver*
dc.subject.meshBrain*
dc.subject.meshGrowth Hormone*
dc.subject.meshInsulin*
dc.titleMetabolic actions of the growth hormone-insulin growth factor-1 axis and its interaction with the central nervous systemes
dc.typeArtigoes
dc.rights.holderLos autoreses
dc.identifier.doihttps://doi.org/10.1007/s11154-022-09732-x
dc.journal.titleReviews in Endocrine and Metabolic Disorderses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostelaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.relation.projectIDISCIII/CP21/00108es
dc.relation.projectIDISCIII/CP20/00146es
dc.relation.projectIDMinisterio de Ciencia e innovación I+D+i 2020 Modalidades Retos de Investigación y Generación de conocimiento/JIN PID2020-114350RJ-I00es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11154-022-09732-x#citeases
dc.rights.accessRightsopenAccesses
dc.subject.decsencéfalo*
dc.subject.decshígado*
dc.subject.decsinsulina*
dc.subject.decshormona del crecimiento*
dc.subject.keywordIDISes
dc.subject.keywordCHUSes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales


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Rev Endocr Metab Disord (2022). https://doi.org/10.1007/s11154-022-09732-x

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