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dc.contributor.authorOlivares Diez, José Manuel 
dc.contributor.authorGonzalez-Pinto, A.
dc.contributor.authorPáramo Fernández, Mario 
dc.contributor.otherProsigo Study Group
dc.date.accessioned2023-03-01T11:50:10Z
dc.date.available2023-03-01T11:50:10Z
dc.date.issued2021
dc.identifier.issn0924-9338
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33840396es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/17354
dc.description.abstractAbstract Background: Poor adherence to antipsychotic drugs is a major problem in schizophrenia management and one of the most important risk factors for relapse and hospitalization. To date, there is little evidence on persistence predictors with long-acting injectable antipsychotics, especially with aripiprazole once-monthly (AOM). This study (NCT03130478) aimed to describe the impact of demographic and clinical characteristics on persistence with AOM treatment in real-world setting. Methods: This was an observational, retrospective, non-interventional study that included adult patients with schizophrenia who were initiated on AOM during a schizophrenia-related hospitalization. Data were retrospectively collected from patients' medical records. The primary variable was persistence with AOM, measured as the number of days from AOM initiation up to all-cause AOM discontinuation during the first six months after treatment index. Results: 140 patients were enrolled and 91 fulfilled the selection criteria. Six months after AOM initiation, 65 (71.4%) patients were still receiving AOM treatment, whereas 26 (28.6%) were not. The mean (standard deviation) time to AOM treatment discontinuation in the first six months was 138.1 (6.8) days, with most of the patients discontinuing at the first 28 days. The risk of AOM discontinuation in the first six months increases 1.05-fold annually since schizophrenia diagnosis (p=0.003); moreover, this risk increases 2.86-fold in patients with concomitant schizophrenia medication at AOM initiation compared to patients without concomitant schizophrenia treatments (p=0.02). Conclusions: Main factors predicting persistence with AOM treatment at six months in clinical practice are fewer years since schizophrenia diagnosis and not receiving concomitant schizophrenia treatments at AOM initiation.
dc.language.isoenes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePredictors of persistence in patients with schizophrenia treated with aripiprazole once-monthly long-acting injection in the Spanish clinical practice: a retrospective, observational study
dc.typeJournal Articlees
dc.authorsophosOlivares, J. M.;Gonzalez-Pinto, A.;Paramo, M.;Grp, Prosigo Study
dc.identifier.doi10.1192/j.eurpsy.2021.23
dc.identifier.sophos44892
dc.issue.number1
dc.journal.titleEUROPEAN PSYCHIATRY
dc.organizationÁrea Sanitaria de Santiago de Compostela e Barbanza::Complexo Hospitalario Universitario de Santiago::Psiquiatría
dc.organizationÁrea Sanitaria de Vigo::Complexo Hospitalario Universitario de Vigo::Psiquiatría
dc.relation.publisherversionhttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/44D14A7552AC27129FEBB653324D4564/S0924933821000237a.pdf/div-class-title-predictors-of-persistence-in-patients-with-schizophrenia-treated-wes
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordCHUVIes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number64


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Attribution-NonCommercial-NoDerivatives 4.0 International
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