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Pain Improvement in Parkinson's Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study
dc.contributor.author | Santos García, Diego | |
dc.contributor.author | Yañez Baña, Rosa María | |
dc.contributor.author | LABANDEIRA GUERRA, CARMEN MARIA | |
dc.contributor.author | Hernando, M. I. C. | |
dc.contributor.author | Cabo López, Iria | |
dc.contributor.author | Paz González, José Manuel | |
dc.contributor.author | ALONSO LOSADA, MARIA GEMA | |
dc.contributor.author | Palmas, M. J. G. | |
dc.contributor.author | CORES BARTOLOME, CARLOS | |
dc.contributor.author | Martínez Miró, Cristina | |
dc.date.accessioned | 2024-01-02T10:02:30Z | |
dc.date.available | 2024-01-02T10:02:30Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2075-4426 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/34442442 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/18443 | |
dc.description.abstract | BACKGROUND AND OBJECTIVE: Pain is a frequent and disabling symptom in Parkinson's disease (PD) patients. Our aim was to analyze the effectiveness of safinamide on pain in PD patients from the SAFINONMOTOR (an open-label study of the effectiveness of SAFInamide on NON-MOTOR symptoms in Parkinson s disease patients) study. MATERIAL AND METHODS: SAFINONMOTOR is a prospective open-label single-arm study conducted in five centers from Spain. In this analysis, a secondary objective of the study, the score in the KPPS (King s Parkinson s Disease Pain Scale) at V1 (baseline) and V4 (6 months +/- 1 month) were compared. Wilcoxon s rank sum test was performed to test the changes from V1 to V4. RESULTS: Forty-four (88%) out of 50 PD patients (age 68.5 +/- 9.12 years; 58% women; 6.4 +/- 5.1 years from diagnosis) completed the study. The KPPS total score was reduced by 43.6% (from 40.04 +/- 36.18 in V1 to 22.60 +/- 21.42 in V4; p < 0.0001). By domains, improvement was observed in musculoskeletal (-35.9%; p = 0.009), fluctuation-related (-51.7%; p = 0.020), nocturnal (-46.1%; p = 0.001), discoloration and/or edema/swelling (-50.4%; p = 0.009) and radicular pain (-40.1%; p = 0.048). A total of 21 adverse events in 11 patients (22%) were reported, five being severe, but not related to safinamide. CONCLUSION: Safinamide is well tolerated and improves pain in PD patients at 6 months. Future studies are necessary to analyze the possible beneficial effect of safinamide on pain in PD patients. | |
dc.language.iso | en | |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Pain Improvement in Parkinson's Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study | |
dc.type | Journal Article | es |
dc.authorsophos | Garcia, D. S.;Bana, R. Y.;Guerra, C. L.;Hernando, M. I. C.;Lopez, I. C.;Gonzalez, J. M. P.;Losada, M. G. A.;Palmas, M. J. G.;Bartolome, C. C.;Miro, C. M. | |
dc.identifier.doi | 10.3390/jpm11080798 | |
dc.identifier.pmid | 34442442 | |
dc.identifier.sophos | 47169 | |
dc.issue.number | 8 | |
dc.journal.title | JOURNAL OF PERSONALIZED MEDICINE | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neuroloxía | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Neuroloxía | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Pontevedra e O Salnés - Complexo Hospitalario Universitario de Pontevedra::Neuroloxía | |
dc.page.initial | 798 | |
dc.relation.publisherversion | https://mdpi-res.com/d_attachment/jpm/jpm-11-00798/article_deploy/jpm-11-00798.pdf?version=1629118625 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUAC | es |
dc.subject.keyword | CHUO | es |
dc.subject.keyword | CHUP | es |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 11 |