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dc.contributor.authorPAEZ GUILLAN, EMILIO MANUEL 
dc.contributor.authorCampos Franco, Joaquín 
dc.contributor.authorAlende Sixto, Rosario 
dc.contributor.authorGaritaonaindía, Y.
dc.contributor.authorGonzález Quintela, Arturo 
dc.date.accessioned2024-01-02T10:02:58Z
dc.date.available2024-01-02T10:02:58Z
dc.date.issued2021
dc.identifier.issn1476-511X
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/34895245es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/18464
dc.description.abstract[EN] BACKGROUND: Hypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis. METHODS: We evaluated an adult patient with severe hypertriglyceridemia (>1000 mg/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (n=75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. RESULTS: The triglyceride concentrations in the acute phase (median: 156 mg/dL) were significantly higher than those of the controls (median, 76 mg/dL; P<0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (>150 mg/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%; P<0.001). A significant correlation (P<0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (P<0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P<0.001). CONCLUSIONS: Patients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.
dc.language.isoen
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleTransient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis
dc.typeJournal Articlees
dc.authorsophosPáez-Guillán, E. M.;Campos-Franco, J.;Alende, R.;Garitaonaindía, Y.;González-Quintela, A.
dc.identifier.doi10.1186/s12944-021-01603-9
dc.identifier.pmid34895245
dc.identifier.sophos44157
dc.issue.number1
dc.journal.titleLipids in Health and Disease
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Medicina Interna
dc.page.initial177
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number20


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