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O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease
| dc.contributor.author | Gonzalez-Rellan, M.J. | |
| dc.contributor.author | Fondevila, M.F. | |
| dc.contributor.author | Diéguez González, Carlos | |
| dc.contributor.author | Nogueiras Pozo, Rubén | |
| dc.date.accessioned | 2025-08-25T12:41:47Z | |
| dc.date.available | 2025-08-25T12:41:47Z | |
| dc.date.issued | 2022 | |
| dc.identifier.citation | Gonzalez-Rellan MJ, Fondevila MF, Dieguez C, Nogueiras R. O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease. Frontiers in Endocrinology. Frontiers Media S.A.; 2022;13. | |
| dc.identifier.issn | 1664-2392 | |
| dc.identifier.other | https://portalcientifico.sergas.gal/documentos/6289747affc02649ba306bb2 | * |
| dc.identifier.uri | http://hdl.handle.net/20.500.11940/20506 | |
| dc.description.abstract | O-GlcNAcylation is a posttranslational modification ruled by the activity of a single pair of enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes carry out the dynamic cycling of O-GlcNAcylation on a wide range of cytosolic, nuclear, and mitochondrial proteins in a nutrient- and stress-responsive manner. To maintain proper glucose homeostasis, a precise mechanism to sense blood glucose levels is required, to adapt cell physiology to fluctuations in nutrient intake to maintain glycemia within a narrow range. Disruptions in glucose homeostasis generates metabolic syndrome and type 2 diabetes. In this review we will discuss and summarize emerging findings that points O-GlcNAcylation as a hub in the control of systemic glucose homeostasis, and its involvement in the generation of insulin resistance and type 2 diabetes. | en |
| dc.description.sponsorship | This work has been supported by grants from FEDER/Ministerio de Ciencia, Innovacion y Universidades-Agencia Estatal de Investigacion (CD: BFU2017-87721; RN: RTI2018-099413-B-I00 and RED2018-102379-T), Xunta de Galicia (RN: 2015-CP080 and 2016-PG057), Fundacion BBVA (RN), Fundacion Atresmedia (RN), European Foundation for the Study of Diabetes (RN). This research also received funding from the European Community's H2020 Framework Programme (ERC Synergy Grant-2019-WATCH- 810331, to RN). CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. | en |
| dc.language.iso | eng | |
| dc.rights | Atribución 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease | * |
| dc.type | Review | en |
| dc.authorsophos | Gonzalez-Rellan, R. M. J. | |
| dc.authorsophos | Fondevila, M. F. | |
| dc.authorsophos | Dieguez, C. | |
| dc.authorsophos | Nogueiras | |
| dc.identifier.doi | 10.3389/fendo.2022.873513 | |
| dc.identifier.sophos | 6289747affc02649ba306bb2 | |
| dc.issue.number | null | |
| dc.journal.title | Frontiers in Endocrinology | * |
| dc.page.initial | null | |
| dc.relation.projectID | FEDER/Ministerio de Ciencia; Innovacion y Universidades-Agencia Estatal de Investigacion [BFU2017-87721, RTI2018-099413-B-I00, RED2018-102379-T]; Xunta de Galicia [2015-CP080, 2016-PG057]; Fundacion BBVA; Fundacion Atresmedia; European Foundation for the Study of Diabetes; European Community's H2020 Framework Programme (ERC Synergy Grant) [2019-WATCH- 810331]; Instituto de Salud Carlos III (ISCIII) of Spain - FEDER funds | |
| dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fendo.2022.873513/pdf;https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.873513/pdf | es |
| dc.rights.accessRights | openAccess | |
| dc.subject.keyword | AS Santiago | es |
| dc.subject.keyword | IDIS | es |
| dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
| dc.typesophos | Artículo de Revisión | es |
| dc.volume.number | 13 |
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