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Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

dc.contributor.authorDiz-Chaves, Y.
dc.contributor.authorMastoor, Z.
dc.contributor.authorSpuch Calvar, Carlos
dc.contributor.authorGonzález-Matías, L.C.
dc.contributor.authorMallo, F.
dc.date.accessioned2025-08-26T09:27:03Z
dc.date.available2025-08-26T09:27:03Z
dc.date.issued2022
dc.identifier.citationDiz-Chaves Y, Mastoor Z, Spuch C, González-Matías LC, Mallo F. Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases. International journal of molecular sciences. NLM (Medline); 2022;23(17).
dc.identifier.issn1422-0067
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/632656abd50fae52cd31b2e6*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20650
dc.description.abstractThe glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.en
dc.description.sponsorshipThe authors have financial support from the European Union Grant Alehoop (H2020BBIJTI-2019-887259). And from the Xunta de Galicia (Centro singular de Investigacion de Galicia accreditation 2016-2019), ED431G/02.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAnti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases*
dc.typeReviewen
dc.authorsophosDiz-Chaves, F. Y.
dc.authorsophosMastoor, Z.
dc.authorsophosSpuch, C.
dc.authorsophosGonzález-Matías, L. C.
dc.authorsophosMallo
dc.identifier.doi10.3390/ijms23179583
dc.identifier.sophos632656abd50fae52cd31b2e6
dc.issue.number17
dc.journal.titleInternational journal of molecular sciences*
dc.relation.projectIDEuropean Union [H2020BBIJTI-2019-887259]; Xunta de Galicia [ED431G/02]
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/17/9583/pdf?version=1661494533;https://mdpi-res.com/d_attachment/ijms/ijms-23-09583/article_deploy/ijms-23-09583-v2.pdf?version=1661494533es
dc.rights.accessRightsopenAccess
dc.subject.keywordIISGSes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo de Revisiónes
dc.volume.number23


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