Mostrar el registro sencillo del ítem

Liver Brain Interactions: Focus on FGF21 a Systematic Review

dc.contributor.authorPrida, E.
dc.contributor.authorÁlvarez-Delgado, S.
dc.contributor.authorPerez Lois, Raquel
dc.contributor.authorSoto-Tielas, M.
dc.contributor.authorEstany Gestal, Ana
dc.contributor.authorFerno, Johan
dc.contributor.authorSeoane Camino, Luisa Maria 
dc.contributor.authorQuiñones, Mar E
dc.contributor.authorAl-Massadi Iglesias, Omar
dc.date.accessioned2025-08-26T10:56:06Z
dc.date.available2025-08-26T10:56:06Z
dc.date.issued2022
dc.identifier.citationPrida E, Álvarez-Delgado S, Pérez-Lois R, Soto-Tielas M, Estany-Gestal A, Fernø J, et al. Liver Brain Interactions: Focus on FGF21 a Systematic Review. International Journal of Molecular Sciences. 2022;23(21).
dc.identifier.issn1422-0067
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/639e327bfe5bc92de889d74f*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20752
dc.description.abstractFibroblast growth factor 21 is a pleiotropic hormone secreted mainly by the liver in response to metabolic and nutritional challenges. Physiologically, fibroblast growth factor 21 plays a key role in mediating the metabolic responses to fasting or starvation and acts as an important regulator of energy homeostasis, glucose and lipid metabolism, and insulin sensitivity, in part by its direct action on the central nervous system. Accordingly, pharmacological recombinant fibroblast growth factor 21 therapies have been shown to counteract obesity and its related metabolic disorders in both rodents and nonhuman primates. In this systematic review, we discuss how fibroblast growth factor 21 regulates metabolism and its interactions with the central nervous system. In addition, we also state our vision for possible therapeutic uses of this hepatic-brain axis.en
dc.description.sponsorshipThis study has been funded by Instituto de Salud Carlos III (ISCIII) through the grant number PI18/00998 (L.M.S.) and PI21/01216 (O.A.-M.) and co-funded by the European Union. GAIN Proyectos de Excelencia with the grants numbers IN607D-2022-07 (O.A.-M.) and IN607D-2022-04 (L.M.S.). Fundacion de la Sociedad Gallega de Endocrinologia y Nutricion (O.A.-M.); Centro de Investigacion Biomedica en Red (CIBER) de Fisiopatologia de la Obesidad y Nutricion (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is supported by FEDER funds; O.A.-M. and M.Q. were funded by a research contract Miguel Servet (CP20/00146 and CP21/00108, respectively) from the ISCIII co-funded by the European Union. The data figures were generated by using materials from Servier Medical Art (Servier) under consideration of a Creative Commons Attribution 3.0 Unported License.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleLiver Brain Interactions: Focus on FGF21 a Systematic Review*
dc.typeReviewen
dc.authorsophosPrida, O. E.
dc.authorsophosÁlvarez-Delgado, S.
dc.authorsophosPérez-Lois, R.
dc.authorsophosSoto-Tielas, M.
dc.authorsophosEstany-Gestal, A.
dc.authorsophosFernø, J.
dc.authorsophosSeoane, L. M.
dc.authorsophosQuiñones, M.
dc.authorsophosAl, Massadi
dc.identifier.doi10.3390/ijms232113318
dc.identifier.sophos639e327bfe5bc92de889d74f
dc.issue.number21
dc.journal.titleInternational Journal of Molecular Sciences*
dc.relation.projectIDInstituto de Salud Carlos III (ISCIII) [PI18/00998, PI21/01216]; European Union; GAIN Proyectos de Excelencia [IN607D-2022-07, IN607D-2022-04]; Fundacion de la Sociedad Gallega de Endocrinologia y Nutricion; Centro de Investigacion Biomedica en Red (CIBER) de Fisiopatologia de la Obesidad y Nutricion (CIBERobn); FEDER funds; ISCIII - European Union [CP20/00146, CP21/00108]
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658462/pdf/ijms-23-13318.pdf;https://mdpi-res.com/d_attachment/ijms/ijms-23-13318/article_deploy/ijms-23-13318.pdf?version=1667293372es
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Santiagoes
dc.subject.keywordIDISes
dc.subject.keywordCHUSes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo de Revisiónes
dc.volume.number23


Ficheros en el ítem

Descargar/
Nombre:
846.pdf
Tamaño:
1.400Mb
Formato:
PDF
Descripción:
Prida E, Álvarez-Delgado S, Pérez-Lois R, Soto-Tielas M, Estany-Gestal A, Fernø ...

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional