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dc.contributor.authorMartí Fuster, B.
dc.contributor.authorEsteban, O.
dc.contributor.authorPlanes, X.
dc.contributor.authorAguiar Souto, Pablo 
dc.contributor.authorCrespo, C.
dc.contributor.authorFalcon, C.
dc.contributor.authorWollny, G.
dc.contributor.authorRubí Sureda, S.
dc.contributor.authorSetoain, X.
dc.contributor.authorFrangi, A. F.
dc.contributor.authorLedesma, M. J.
dc.contributor.authorSantos, A.
dc.contributor.authorPavía, J.
dc.contributor.authorRos, D.
dc.date.accessioned2017-06-07T07:11:30Z
dc.date.available2017-06-07T07:11:30Z
dc.date.issued2013
dc.identifier.issn1559-0089
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3635
dc.description.abstractSubtraction of Ictal SPECT Co-registered to MRI (SISCOM) is an imaging technique used to localize the epileptogenic focus in patients with intractable partial epilepsy. The aim of this study was to determine the accuracy of registration algorithms involved in SISCOM analysis using FocusDET, a new user-friendly application. To this end, Monte Carlo simulation was employed to generate realistic SPECT studies. Simulated sinograms were reconstructed by using the Filtered BackProjection (FBP) algorithm and an Ordered Subsets Expectation Maximization (OSEM) reconstruction method that included compensation for all degradations. Registration errors in SPECT-SPECT and SPECT-MRI registration were evaluated by comparing the theoretical and actual transforms. Patient studies with well-localized epilepsy were also included in the registration assessment. Global registration errors including SPECT-SPECT and SPECT-MRI registration errors were less than 1.2 mm on average, exceeding the voxel size (3.32 mm) of SPECT studies in no case. Although images reconstructed using OSEM led to lower registration errors than images reconstructed with FBP, differences after using OSEM or FBP in reconstruction were less than 0.2 mm on average. This indicates that correction for degradations does not play a major role in the SISCOM process, thereby facilitating the application of the methodology in centers where OSEM is not implemented with correction of all degradations. These findings together with those obtained by clinicians from patients via MRI, interictal and ictal SPECT and video-EEG, show that FocusDET is a robust application for performing SISCOM analysis in clinical practice.
dc.language.isoeng
dc.subject.meshAlgorithms
dc.subject.meshBrain/*diagnostic imaging
dc.subject.meshDiagnostic Errors
dc.subject.meshElectroencephalography
dc.subject.meshEpilepsies, Partial
dc.subject.meshHumans
dc.subject.meshImage Interpretation, Computer-Assisted
dc.subject.meshImage Processing, Computer-Assisted
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMonte Carlo Method
dc.subject.meshSubtraction Technique
dc.subject.meshTomography, Emission-Computed, Single-Photon
dc.titleFocusDET, a new toolbox for SISCOM analysis. Evaluation of the registration accuracy using monte carlo simulation
dc.typeArtigoes
dc.authorsophosMartí Fuster, B.
dc.authorsophosEsteban, O.
dc.authorsophosPlanes, X.
dc.authorsophosAguiar, P.
dc.authorsophosCrespo, C.
dc.authorsophosFalcon, C.
dc.authorsophosWollny, G.
dc.authorsophosRubí Sureda, S.
dc.authorsophosSetoain, X.
dc.authorsophosFrangi, A. F.
dc.authorsophosLedesma, M. J.
dc.authorsophosSantos, A.
dc.authorsophosPavía, J.
dc.authorsophosRos, D.
dc.identifier.doi10.1007/s12021-012-9158-x
dc.identifier.pmid22903439
dc.identifier.sophos13435
dc.issue.number1
dc.journal.titleNeuroinformatics
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago::Fundación Ramón Domínguez
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Medicina nuclear
dc.page.initial77
dc.page.final89
dc.relation.publisherversionhttps://link.springer.com/content/pdf/10.1007%2Fs12021-012-9158-x.pdf
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number11


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