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dc.contributor.authorPazos Mendoza, Patricia
dc.contributor.authorLima Rodríguez, Luis
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorGarcía García, María del Carmen
dc.date.accessioned2017-06-07T07:22:37Z
dc.date.available2017-06-07T07:22:37Z
dc.date.issued2014
dc.identifier.issn1687-8337
dc.identifier.urihttp://hdl.handle.net/20.500.11940/5722
dc.description.abstractThe placenta produces a number of signaling molecules including metabolic and reproductive hormones as well as several inflammatory mediators. Among them, Interleukin-6 (IL-6), a well-known immune and metabolic regulator, acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. IL-6 interacts with key hypothalamic neuropeptidergic systems controlling energy homeostasis such as those producing the orexigenic/anabolic: neuropeptide Y (NPY) and agouti-related peptide (AgRP) and anorectic/catabolic neuropeptides: proopiomelanocortin (POMC) and cocaine and amphetamine regulated transcript (CART). Human and rat placenta have been identified as source of these neuropeptides, but their expression and regulation in murine placental tissues remain unknown. Therefore, placental mRNA levels of IL-6, NPY, AgRP, POMC, and CART at different pregnancy stages (gestational days 13, 15, and 18) were analyzed by real time PCR, as were the effect of IL-6 deficiency (IL-6 knockout mice) on their placental expression. Our results showed that placenta-derived neuropeptides were regulated by gestational age and IL-6 throughout the second half of mouse pregnancy. These data suggest that IL-6 may participate in the fine tune control of energy balance during pregnancy by extending its action as a metabolic signal to the main organ at the fetomaternal interface: the placenta.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshPregnancy
dc.subject.meshNeuropeptides
dc.subject.meshInterleukin-6
dc.subject.meshAnimals
dc.titleEnergy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta
dc.typeArtigoes
dc.authorsophosPazos, P.
dc.authorsophosLima, L.
dc.authorsophosDiéguez, C.
dc.authorsophosGarcía, M. C.
dc.identifier.doi10.1155/2014/537603
dc.identifier.isi333424700001
dc.identifier.pmid24744782
dc.identifier.sophos14912
dc.journal.titleInternational Journal of Endocrinology
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial537603
dc.rights.accessRightsopenAccess
dc.subject.decsEmbarazo
dc.subject.decsNeuropéptidos
dc.subject.decsInterleucina-6
dc.subject.decsAnimales
dc.typesophosArtículo Original
dc.volume.number2014


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