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Predictive factors of functional capacity and real-world functioning in patients with schizophrenia

Menendez-Miranda, I.; Garcia-Portilla, M. P.; Garcia-Alvarez, L.; Arrojo Romero, Manuel; Sanchez, P.; Sarramea, F.; Gomar, J.; Bobes-Bascaran, M. T.; Sierra, P.; Saiz, P. A.; Bobes, J.
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URI: http://hdl.handle.net/20.500.11940/69
PMID: 25681175
DOI: 10.1016/j.eurpsy.2014.12.011
ISSN: 0924-9338
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Eur Psychiatry . 2015 Jul;30(5):622-7. doi: 10.1016/j.eurpsy.2014.12.011. (259Kb)
Acceso a la versión del editor (12.62Kb)
Fecha de publicación
2015
Título de revista
EUROPEAN PSYCHIATRY
Tipo de contenido
Artigo
DeCS
Actividades Cotidianas | Adaptación Psicológica | Adulto | Ajuste Social | Análisis de Regresión | Análisis y Desempeño de Tareas | Esquizofrenia | Femenino | Humanos | Masculino | Persona de Mediana Edad | Psicología del Esquizofrénico | Psicometría
MeSH
Activities of Daily Living | Adaptation, Psychological | Adult | Female | Humans | Male | Middle Aged | Psychometrics | Regression Analysis | Schizophrenia | Schizophrenic Psychology | Social Adjustment | Task Performance and Analysis | Functional capacity | Predictive factors | Real-world functioning | Schizophrenia
Resumen
PURPOSE: This study was performed to identify the predictive factors of functional capacity assessed by the Spanish University of California Performance Skills Assessment (Sp-UPSA) and real-world functioning assessed by the Spanish Personal and Social Performance scale (PSP) in outpatients with schizophrenia. METHODS: Naturalistic, 6-month follow-up, multicentre, validation study. Here, we report data on 139 patients with schizophrenia at their baseline visit. ASSESSMENT: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S), Sp-UPSA and PSP. STATISTICS: Pearson's correlation coefficient (r) was used to determine the relationships between variables, and multivariable stepwise linear regression analyses to identify predictive variables of Sp-UPSA and PSP total scores. RESULTS: Functional capacity: scores on the PSP and PANSS-GP entered first and second at P<0.0001 and accounted for 21% of variance (R(2)=0.208, model df=2, F=15.724, P<0.0001). Real-world functioning: scores on the CGI-S (B=-5.406), PANSS-N (B=-0.657) and Sp-UPSA (B=0.230) entered first, second and third, and accounted for 51% of variance (model df=3, F=37.741, P<0.0001). CONCLUSION: In patients with schizophrenia, functional capacity and real-world functioning are two related but different constructs. Each one predicts the other along with other factors; general psychopathology for functional capacity, and severity of the illness and negative symptoms for real-world functioning. These findings have important clinical implications: (1) both types of functioning should be assessed in patients with schizophrenia and (2) strategies for improving them should be different.

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